Améliorer la sécurité des patients en développant un algorithme permettant de surveiller la fonction respiratoire des patients lors de l’administration de Remifentanil lors d’une lithotripsie

Le Remifentanil, un anesthésique qui est administré par voie intraveineuse au cours du traitement des calculs rénaux par ondes de choc acoustiques, ralentit la capacité des patients à respirer et peut mener à l’apnée. Habituellement, la respiration est détectée au moyen de moniteurs standard qui déclenchent une alarme lorsque le patient cesse de respirer pendant […]

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Evaluation of a radiomic approach based on hyperspectral retinal imaging to predict the cerebral amyloid status for the diagnosis of Alzheimer’s disease

The project will help Optina validate and further develope a novel technology to predict the presence of significant amyloid (A?) deposition in the brain from a simple, non-invasive hyperspectral retina scan in combination with an artificial intelligence algorithm. Accumulation of A? plaques in the brain is a key hallmark of Alzheimer’s disease (AD), but current […]

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Implantation et validation d’une nouvelle approche de navigation chirurgicale en chirurgie orthopédique

Malgré la précision inhérente des éléments matériels des systèmes de navigation chirurgicale existants, la façon dont ils sont couramment utilisés en chirurgie orthopédique introduit une imprécision en limitant l’intérêt clinique. Les chirurgies pratiquées comportent des étapes importantes pouvant bénéficier d’un guidage fiable et reproductible pour leur réalisation afin d’en optimiser le résultat, entre autres en […]

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Tuning in to emotions of non-communicative persons

Many individuals who have severe disabilities or who have suffered traumatic injury are unable to move or speak, and hence, unable to communicate with their family and caregivers. The physiological systems of these individuals are typically functional and can change to reflect the unexpressed mental and emotional states of these otherwise non-communicative persons. In this […]

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Tensor based machine learning with human computer interaction applications

In this research, first we will using tensor network techniques speedup the processing in neural network since computational cost is a major bottleneck in neural network based deep learning. Note that the weight matrix in each layer of neural network is with huge size, because of millions of parameters. This may cause large time complexity […]

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Enhancing Electrical Neuromodulation of Bladder Function in Anesthetized Rats

Overactive bladder (OAB) is an incurable, chronic medical condition that is characterized by symptoms of urgency, frequency, nocturia and urinary incontinence. It affects approximately 18% of adults and over 30% of the elderly population. Saphenous nerve stimulation is a novel therapy aimed at treating OAB patients. It offers an alternative to bladder medication, which can […]

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Validation of SIMBA capsules for small intestine sampling

The aim of this research and development project for the intern student is to assist in validation tests (both in-vitro and in-vivo) of a GI sampling capsule device being developed by the organization and translate the testing results and the new knowledge to technical documents for the potential customers and partners of the organization. In-vitro […]

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Assessing the impact of cell positioning via micropatterning on throughput, precision, and reproducibility of cell-based tests

In recent years, the concern with data reproducibility in preclinical research data has increased significantly. A survey performed by Nature showed more than 70% of published research is not reproducible and the issue is more concerning when it comes to biomedical research with only 10% of published work able to be reproduced. Scientists study the […]

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Development of the library of nanoparticle contrast probes for tissue clearing 3D microscopy compatible with multi-modal imaging in fluorescence, dark field, MRI, CT and electron microscopy modalities

High resolution 3D microscopy is a rapidly growing area of biomedical research, which has high potential to replace traditional 2D histology used for the analysis of tissue biopsies of cancer and other diseases. However, currently there is a limited availability of contrast agents that can label organs, biological tissues, and cells in a live animal […]

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Multiplexed confocal FLIM microscope for Drug Discovery

Fluorescence lifetime imaging (FLIM) is an emerging technique that is used drug discovery by universities and pharmaceutical companies. The research team developed a multiplexing technique that can improve the imaging speed by 1000 times. However, matching 1000 focal points to 1000 detectors individually is very difficult. In this project, the team plans to develop a […]

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