Mutations in the enzyme glucocerebrosidase (GBA1) are the most common genetic risk factor for development of Parkinson’s disease (PD). PD is characterized by the buildup of abnormal protein deposits in the brain, followed by progressive loss of neurons and behavioural symptoms. Numerous studies have noted a correlation between reduced GBA1 activity and increased levels of […]

As the general population ages the incidence of Alzheimer’s disease (AD), the leading cause of dementia, has dramatically increased in recent years. One of the main hallmarks of this disease is the buildup of amyloid beta peptides in the brain. This peptide is capable of damaging the cell membranes of neurons and aggregating into plaques […]

Retinal diseases, such as age-related macular degeneration (AMD), cause vision blur and distortion, eventually leading to vision loss. AMD is the leading cause of blindness in patients over 60, affecting an estimated 200 million people worldwide. Current treatments require patients to receive monthly injections into the back of the eye, risking adverse effects and placing […]

This project aims to develop a method for delivering reprogramming transcription factor genes to astrocytes in the central nervous system using Intelligent Phagemid-Assembled Gene Expression (iPhAGE) technology. By constructing specific gene blocks and fusion helper plasmids, synthesizing iPhAGE DNA, and purifying iPhAGE preparations, the project seeks to enhance transfection efficiency and assess immune responses and […]

Cyanobacterial and microalgal host cells produce a range of bioactive compounds that makes them good candidates for drug discovery. At the same time, they themselves get infected by a range of different viruses. This means that understanding the interplay of these hosts with the viruses that infect them is crucial in order to optimize bioactive […]

Our solution, AthleteAid is an mobile-app based service which compiles tried and tested medical decision rules and advice into a condensed, easy to follow step by step protocols. These protocols will alleviate stress and provide guidance for parents and coaches making decisions as well as reduce the amount of costly and unneccearry hospital trips. Using […]

GamBit enables users to control gameplay directly with their thoughts, offering a new level of accessibility and immersion. Through seamless integration with popular video games, GamBit empowers users to experience the thrill of gaming like never before.

Tuberculosis is one of the leading causes of mortality and morbidity worldwide with more than 1.3 million deaths reported in 2023. With the increase in multidrug resistant cases of TB, it is important for us to develop newer and faster acting drugs to treat TB. In addition, one-quarter of the world’s population carries a latent […]

Single-cell -Omics analysis methods are having a transformational impact on research in the life sciences. Specifically, the capacity to assess genomes, transcriptomes, or proteomes of individual cells in place of (or in addition to) measuring the average signals from populations of cells allows researchers to ask and answer questions that have never been accessible until […]

This project proposes a comprehensive analysis of the impact of environmental stress on Antarctic fish, utilizing an integrated approach that combines biophysical and genomic analyses to study adaptation mechanisms. By integrating disciplines, including physics and biology, this research aims to enhance our understanding of evolutionary processes and adaptation strategies of organisms in extreme environments, such […]

The project is focused on study of commercial microbial cultures for biological remediation of soils and ground waters contaminated by chlorinated organic. The successful elaboration and improvement of the products requires analysis on molecular-genetic level and developing of specific techniques (16S pyrotag pipeline) for microbial communities profiling and metabolic reconstruction. The work benefits to industry […]

The clinical translation of innovative oncology treatments can be boosted by the establishment of alternative in vivo models based on the chick chorioallantoic membrane. In this project, a biomodel based on commercial cancer cell lines, such as hepatocellular carcinoma, will be established and characterized by standard biological assays. The biomodels will be employed for the […]