An Omnigenic Hypothesis to Predict Human Gene Regulatory Networks

The project mainly focuses on the cellular behaviour and ways to predict human gene interactions. Using a method called Proteinfragment Complementation Assays, we are able to compute the biochemical networks in living cells. The results of this project will provide a novel and highly efficient way to establish hypotheses about the organization of cellular regulatory […]

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Cloning, expression and characterization of a novel gene involved in Amaryllidaceae alkaloid metabolism

Amaryllidaceae alkaloids (AAs) are a group of specialized metabolites found predominantly in the Amaryllidaceae plant family. Approximately 650 naturally occurring AAs have been identified, many of which possess a variety of potent biological and pharmacological properties. In contrast to the large body of knowledge on the pharmacological and phytochemical aspects of AAs, their molecular and […]

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Characterizing the genetic architecture of agronomic and quality traits, and deleterious mutations in common bean (Phaseolus vulgaris L.)

Common bean is a promising commodity to ensure food security and increase diet quality due to its high content of protein, minerals, and vitamins. To contribute to the increase of the genetic gain in breeding programs for agronomic and quality traits, the project aims to study the genetic architecture of agronomic and quality traits, and […]

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Transformation of the moss Physcomitrium patens

This project will provide essential technical support and experimental plant materials for my Ph.D. project studying the leaf development of a non-vascular plant, the Physcomitrium patens. The mutant lines I will obtain from this project will be used to study the whole developmental process of the moss leaf. The mutant line with a plasma membrane […]

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Collective dynamics of interacting cells during development

Multicellular organisms begin as a single cell with instructions encoded by the genome. During development this cell multiplies many times generating an enormous number of cells, each with its own specialized role. For example, developed humans are composed of trillions of cells but our organs and limbs have the right form, location, and function with […]

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Optimisation de l’efficacité antimicrobienne des dons de granulocytes destinés à la transfusion.

Le but de cette recherche est d’améliorer les propriétés thérapeutiques d’un produit sanguin qui peut sauver des vies des patients avec une infection sévère due à un système immunitaire affaiblie. Ces patients ont un nombre insuffisant de neutrophiles ou des neutrophiles qui ne fonctionnent pas très bien. Les neutrophiles sont des globules blancs qui jouent […]

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Engineering of glycan-binding proteins for mapping cancer glycomics

Over the last decade, chemical biology approaches have proven increasingly successful, delivering new solutions to problems that were previously unresponsive to traditional chemical and biochemical techniques. In the fields of proteomics and genomics, new diagnostics and therapeutic strategies are revolutionizing healthcare. However, in the field of glycomics, tractable strategies to study glycan (carbohydrate)-mediated processes remain […]

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