INVESTIGATION INTO ANTI-DIABETIC, ANTI-MICROBIAL AND HYPOLIPIDEMIC PROPERTIES OF SORBUS DECORA USED IN THE MANAGEMENT OF DIABETES – EFFECTS ON PI3-K/AKT SIGNALLING PATHWAY

Diabetes mellitus (DM) is a metabolic disease, which is characterized by insufficient or inefficient insulin secretory response and elevated blood glucose level (Prabhakar and Doble, 2008). In 2021, 536.6 million people worldwide suffered from diabetes and this number is projected to grow to 783.2 million by 2045 (Sun et al., 2022). Sorbus decora (SD), commonly […]

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In vitro tissue culture methods for ornamental propagation and new varietal development

The innovation of plant cell and tissue culture (TC) techniques has supported plant propagation programs and allowed for the development of new ornamental varieties. Van Belle Nursery is interested in adapting TC as a method of cultivation but lack the technical expertise and understanding of infrastructure requirements to establish an on-site TC program. Specifically, they […]

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Isolation, characterization and culture maintenance of stem cells from human hair follicle mesenchyme Year Two

Stem cells and other pluripotent cells are under active investigation for the development of new therapeutic treatments to regenerate and repair diseased and damaged tissues. Published studies indicate that some mesenchymal cells derived from adult human hair follicles exhibit stem cell properties and can form different cells types if they are given specific biological signals […]

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Development of chemical approaches and technology for the design and preparation of glycoconjugate vaccines.

Glycoconjugate vaccines have shown efficiency to control infectious diseases and hold great promises in cancer immunotherapy. Nonetheless, there is an important need to identify novel immunostimulating carriers for carbohydrate antigens as well as to optimize the currently used protein carriers. This Mitacs project aims at developing versatile biochemical approaches and technology for the design and […]

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Production of cellulose esters in ionic liquid

Cellulose is the most common natural polymer available. The project aims to produce esters from cellulose fibers employing green solvents, such as ionic liquids. Ionic liquids’ properties are tunable by changing the anion and the cation to dissolve simultaneously the cellulose and the esterification agent. The esterification agent is a free fatty acid which can […]

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Temporal Preferences versus Song Learning Across Populations of Ormia ochracea

This project will measure the behavioural responses in a certain fly species, ‘Ormia ochracea’, to a variety of cricket mating songs, and from geographically separated North American populations of the fly. This type of fly attacks crickets so that their larvae may feed and mature within the cricket’s body. They locate the cricket’s position by […]

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DEVELOPMENT OF CONTEXT-SPECIFIC INTEGRATED BIOLOGICAL NETWORK MODELS WITH APPLICATIONS TO STRAIN ENGINEERING

Biological-system-based production of chemicals and fuels (Eg: ethanol, bio-diesel, bio-nylon, etc.) has lesser or no impact on the environment than their conventional, chemical processes But, these biofactories are not evolved to produce industrially important chemicals yet. Hence, the productivity of the desired chemical is low in an isolated biological system. Metabolic engineering modifies the metabolic […]

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Development of innovative solutions for analyzing biological samples in pharmaceutical research and development: Novel bioanalytical chemistry merges digital microfluidics and massspectrometry

Diagnostic tests that currently direct patient therapy in cancer and other diseases are more typically performed at the genetic level, despite the fact that the beneficial response to drugs and the development of resistance are rooted in the proteins that comprise the cell’s signaling pathways. We argue that this is a major gap, as proteomics […]

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Evaluation of phytochemicals bioavailability and antioxidant capacity in South African common indigenous foods

Phytochemicals are secondary metabolites that offer biological activity to prevent degeneration of different non-communicable diseases such as type-2 diabetes (Stroke), cardiovascular disease, and cancer. Indigenous food crops are rich source of phytochemicals such as phenolic acids and flavonoids which have demonstrated some biological activities including antioxidant, anti-inflammation and anti-bacterial effect. This study aims to screen […]

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Conductive Hydrogels for neurohybrid interfaces (CHORE)

CHORE aims at the design of a biohybrid synapse between biological neuronal cells and organic neuromorphic devices made of CHORE aims at the design of a biohybrid synapse between biological neuronal cells and organic neuromorphic devices made of a conjugated polymer-based hydrogel which is sentitive to ions released by ther biologtical counterpart. The project icludes […]

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Bioréparation des fissures du béton – Amélioration de la robustesse et validation sur des ouvrages en service

La bioréparation d’une fissure d’un béton a pour but de la colmater pour empêcher le passage de l’eau. Actuellement, deux types d’ouvrages sont principalement ciblés : les ouvrages hydrauliques et les voutes des tunnels en béton. Le colmatage est accompli en injectant, dans la fissure, un liquide nutritif contenant des bactéries. Ces bactéries produisent du […]

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