Oral cancer is one of the most aggressive forms of cancer, and the incidence of new cases and mortality is rising worldwide. Currently, oral cancer is treated with chemotherapy agents alone or in combination with radiotherapy or surgery. Chemotherapeutic approaches made the patients suffer from severe side effects and drug resistance. Henceforward, the current focus […]

Our project is to discover a more effective way to treat oral cancer that includes Eugenol and Carnosol and its derivatives that are effective in treating different types of cancer and also examining their beneficial (preventive and therapeutic) effects. The specific objectives: 1) To study the antimicrobial and anti-inflammatory effects of these two compounds as […]

Myocardial infarction is among the most prominent causes of death worldwide. Following cardiac injury, changes in the composition of the extracellular matrix trigger inflammatory and fibrotic responses. Particularly, left ventricular remodeling and cardiac fibrosis are characterized by pathological glycosaminoglycan (GAG) production and ECM rearrangement, which contribute to cardiomyocyte death and subsequent heart failure. Additionally, chondroitin […]

The overarching objective of this proposal is to develop and validate a new, robust and reproducible 3D culture system that supports the clonal growth of primary sources of normal and malignant human epithelial cells and that is suitable for commercialization by STEMCELL Technologies who will partner in its development. The work will systematically address 3 […]

This research and development project intends to improve the performance of a dental implant stability measurement (ISMS) device made by Prefail Dental Solutions Inc. The technical improvements proposed by this project includes (i) developing an impeoved and reliable signal processing technique, (ii) designing a calibration unit, (iii) designing a new tip for the ISMS clinical […]

Recent advances in stem cell research have shown the use of silk cultures as an effective and timely method to grow and test stem cell cultures. Silk cultures have the propensity to incorporate bioactive ques, either covalently linked to the protein, or physically adsorbed. With the use of silk material, this proposed project will investigate […]

Central hypersomnolence disorders are characterised by excessive daytime sleepiness (EDS) and strongly affect patients’ quality of life. A lack of awareness, as well as poorly understood underlying biology is hindering early identification and adequate treatment of hypersomnolence disorders. Ultimately, strongly reduced daytime functioning and quality of life in patients with central hypersomnolence disorders presents a […]

The Cansbridge Fellowship provides a chance for a select group of Canada’s most ambitious students to join an international network of innovators who are learning and innovating on a global scale. This project is based on the Cansbridge Fellowship’s desire to explore designing innovative medical devices to help improve diagnostic methods used in the industry […]

Les facteurs de croissance stimulent la prolifération cellulaire. Ils agissent à travers des récepteurs situés à la surface cellulaire et activent des réseaux de signalisation complexes menant à l’expression des gènes. Un contrôle particulièrement efficace de cette signalisation s’exerce par le retrait du récepteur de la membrane plasmique par endocytose. Nous avons récemment montré que […]

Gene therapy has risen as one of the more promising treatment options for disorders of the central nervous system (CNS). Using modified viruses to deliver genetic material has shown success however has several disadvantages including increased safety risks. Using a non-viral vector system has the potential to overcome many of the challenges that arise with […]

Les macrophages sont des cellules immunitaires essentielles pour la défense de l’organisme face à une blessure ou une infection. Cependant, leur recrutement dérégulé peut devenir problématique dans certains contextes pathologiques. Ainsi, dans la grande majorité des cancers solides, l’infiltration massive des macrophages favorise la progression de la maladie, et il est devenu crucial de déchiffrer […]

Les causes des maladies cardiovasculaires sont multifactorielles; certaines sont génétiques, d’autres liées intimement aux habitudes de vie et d’autres tombent dans ce qu’on appelle l’épigénétique. Ce domaine étudie les influences environnementales sur l’expression de nos gènes et se subdivise en plusieurs sous-spécialités de recherche. Au cours de notre projet, nous étudierons les influences des protéines […]