Development of a personalized in-vitro model for dystrophic muscle endogenous repair for drug discovery

Duchenne muscular dystrophy (DMD) is a genetic disorder resulting in progressive muscle degeneration. Satellos Bioscience Inc is developing small molecule drugs that target and modulate DMD muscle stem cells to repair the dystrophic muscle. Despite the advantages of DMD animal models, they are not always predictive of human DMD phenotypes, or their response to drug […]

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Formulating a novel goat-whey based drink and studying its nutritional and health functions – Year two

This project will create novel goat milk-based products and test their health effects in healthy adults. Interest in goat milk is increasing, mainly due to two market trends: consumers’ new taste trends for niche/ethnic products, and the perception of goat milk having added health properties. Goat milk is perceived as having intestinal anti-inflammatory effects and […]

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Root associated microbiome of trees growing in a fractured bedrock toluene phytoremediation site

Phytoremediation is a promising in-situ technology that uses plants and its associated microorganisms (particularly bacteria and fungi) to clean up contaminated soils. The efficacy of these processes however, requires an in-depth knowledge on the diversity of microbial communities closely interacting with plant roots. Several studies have demonstrated that plants growing in contaminated soils select for […]

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Formulation and Process Optimizations for the Manufacturing of Cannabinoid Nanoemulsions

Coming into force in October 2019, amendments to the Canadian Cannabis Regulations will introduce guidelines governing the legal production and sale of cannabis-infused extracts, edibles, beverages and topicals. These new products are at the forefront of the natural health product (NHP) and consumer packaged goods (CPG) industries, but challenges associated with their formulation, production and […]

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Plant level implementation of a model for real time tracking and control of composition changes to steel, slag and inclusions during ladle processing – Part 2

The Ladle Metallurgy Furnace is used for adjustment of chemical composition and temperature, and control of tiny particles called “inclusions”. Controlling inclusions is carried out by adding calcium to modify the solid alumina or magnesium aluminate inclusions to less harmful liquid inclusions. During ladle process, reaction of top slag, steel and inclusions occur simultaneously. Therefore, […]

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Development of a comprehensive feminist performance evaluation framework for international Sexual-and-Reproductive-Health-and-Rights (SRHR) development programs: The case of Inter Pares

The main objective of this short-term Mitacs project is to gather evidence through research to support Inter Pares’ development of Performance Evaluation Framework for their upcoming SRHR program, which aims to improve the sexual and reproductive health and rights of women and adolescent girls in the global south. To learn from the program implementation and […]

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Determination of Structural Behavior of UHPC Decked-I-Beam

This Mitacs project will develop and determine the structural performance of a novel bridge construction method using precast girders and precast deck slabs made of ultra high-strength and durable concrete. Full-scale tests and computer simulations will be conducted to accomplish the goal of this project. The test data obtained from this study will be analysed […]

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Goal-oriented Safety-Guided Design and Assurance for FinTech

With the increasing popularity of digital assets such as cryptocurrencies, many financial technology (FinTech) systems have become safety critical. However, current FinTech system development approaches often lack the rigorous safety practices found in the aerospace, nuclear, automotive, and military industries. To address safety concerns of FinTech stakeholders (users, but also regulators and financial institutions), this […]

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Connections Design in New Double Wythe Insulated Wall Panel Containing Ultra-High Performance Concrete (UHPC)

Ultra-high-performance concrete (UHPC) double wythe panels are commonly used in building envelopes, however, the connections between panels have not been investigated properly. Several design connections will be designed and tested in association with the industrial partner to determine the feasibility of the designs. The project will investigate the structural behaviour and strength of different connections […]

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Further improvements of image analysis for multiplexed microarrays – Part 2

Microarray testing allows high-volume analysis. This work will develop tools for accelerated analysis and modifications to surfaces used within the partner facilities. The goal is to enhance the performance of current assay designs and to inform and guide the next-generation of assay designs (ie 384 well plates) which will support the partner’s technology leadership position. […]

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A Dynamic Predictive Lead Scoring System for Inside Sales

Lead scoring is essential for lead management. The result of lead scoring is a list consists of leads with scores assigned indicating how likely each lead can be converted into the next stage of sales process. The Lamb or Spam and the Rule-Based are the two lead scoring methods that have been discussed in the […]

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