Innovative Projects Realized

Explore thousands of successful projects resulting from collaboration between organizations and post-secondary talent.

29670 Completed Projects

2811
AB
4990
BC
801
MB
663
NL
825
SK
8841
ON
9197
QC
95
PE
568
NB
1088
NS

Projects by Category

Chromosome Engineering for Bioproducts from Methanotrophs – Year Two

Currently Metagenom Bio Inc. offers contract research services in environmental microbial species profiling. Applications for this service include the monitoring of biogas operations, greenhouses, and mining processes. Metagenom Bio wishes to offer solutions that use microbes to generate value-added products. Biogas reactors can break down waste products and produce methane, or natural gas. This methane can be burned, or some of it may be used to create materials using bacteria that can consume methane. These bacteria are the methanotrophs, and some of them are able to make polymers that can be used as bioplastics. These bioplastics are biodegradable, biocompatible, and they are suited for use in medical applications and food packaging applications among others. We plan to use genome engineering methods to engineer methanotrophs so that we can use them to create a range of bioplastics for various industrial applications requiring desired physical properties.

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Faculty Supervisor:

Andrew Doxey

Student:

Partner:

Metagenom

Discipline:

Life Sciences

Sector:

Biotechnology; Clean Technology; Agriculture and Food

University:

University of Waterloo

Program:

Elevate

Chromosome Engineering for Bioproducts from Methanotrophs

Currently Metagenom Bio Inc. offers contract research services in environmental microbial species profiling. Applications for this service include the monitoring of biogas operations, greenhouses, and mining processes. Metagenom Bio wishes to offer solutions that use microbes to generate value-added products. Biogas reactors can break down waste products and produce methane, or natural gas. This methane can be burned, or some of it may be used to create materials using bacteria that can consume methane. These bacteria are the methanotrophs, and some of them are able to make polymers that can be used as bioplastics. These bioplastics are biodegradable, biocompatible, and they are suited for use in medical applications and food packaging applications among others. We plan to use genome engineering methods to engineer methanotrophs so that we can use them to create a range of bioplastics for various industrial applications requiring desired physical properties.

View Full Project Description
Faculty Supervisor:

Andrew Doxey

Student:

Partner:

Metagenom

Discipline:

Life Sciences

Sector:

Biotechnology; Clean Technology; Agriculture and Food

University:

University of Waterloo

Program:

Elevate

Development of Cell-Based Functional Assays to Accelerate Commercialization and Therapeutic Application of Recombinant Antibodies

Antibodies are the fastest growing segment of the pharmaceutical market, and with modern engineering technologies antibodies can be programmed to target devastating diseases. Within the immune system, antibodies fight invading bacteria and viruses. High-quality synthetic antibodies directed to disease-related targets have immense therapeutic potential. Development of cell-based assays to enable rapid identification of functionally active antibodies is a critical step in the commercialization process. The proposed research project will involve screening of binders against disease-associated targets; antibodies showing clinical relevancy will be considered for entry into the clinical trial pipeline. The newly formed Centre for the Commercialization of Antibodies and Biologics (CCAB) will bridge the research and discovery occurring at the Donnelly Centre with industry partners to enable accelerated delivery of new therapies to fight diseases such as cancer, arthritis, and Crohn’s disease. CCAB will facilitate commercialization of antibodies by leveraging a world-class technology platform and experienced product development professionals.

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Faculty Supervisor:

Jason Moffat

Student:

Partner:

Centre for the Commercialization of Antibodies and Biologics

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Toronto

Program:

Elevate

Competitive differentiation of VAL-083 as a treatment alternative in non-small cell lung cancer (NSCLC)

Non-small cell lung cancer is the leading cause of cancer deaths worldwide. Resistance to treatments results in a very poor long-term prognosis. VAL-083 is a chemotherapeutic drug that has activity against lung cancer in cell-studies and in clinical trials. It may be an effective treatment option for drug-resistant lung cancer. However, the detailed mechanism of VAL-083 activity in cancer cells is still unclear. The proposed internship project aims to determine the mechanism and resulting effects of VAL-083 in lung cancer cells. Understanding the mechanism allows DelMar to identify cancer patients who will benefit the most from VAL-083 treatment. It further aids DelMar in combining VAL-083 with other drugs to obtain maximum efficacy in lung cancer patients.

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Faculty Supervisor:

Mads Daugaard

Student:

Partner:

Del Mar Pharmaceuticals Ltd

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

The University of British Columbia

Program:

Accelerate

Reduced-Complexity Radio Resource Management Algorithms for Heterogeneous MIMO Cellular Networks

Future broadband cellular systems will require very high throughput data transmission to satisfy ever increasing demands of mobile users for high speed multimedia services. Using innovative approaches to multiantenna transmission/reception and to cooperation of network nodes the achievable data rates can be greatly increased. Two significant obstacles to achieving very high data rates are interference and network latency. In this project, we shall attempt to reduce interference by introducing novel methods and algorithms to coordinate
transmissions from clusters of network nodes. Also, we will investigate the detrimental effect of delayed channel state information on the performance of the proposed algorithms, and will introduce techniques mitigating it. This project is of great interest to its partners and its outcomes are expected to be of significant relevance and benefit to the design and operation of future wireless networks.

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Faculty Supervisor:

Witold Antoni Krzymien

Student:

Partner:

TELUS (Ottawa, ON);TRTech (Edmonton, AB)

Discipline:

Engineering

Sector:

Professional, scientific and technical services

University:

University of Alberta

Program:

Accelerate

Neural and autonomic correlates of post-traumatic stress disorder during processing of trauma-related stimuli

Post-traumatic stress disorder (PTSD) emerges after the exposure to an event that elicits horror or helplessness, including threat of injury or death to one’s self or another person. Community-based studies have evaluated its occurrence with a lifetime prevalence of 9.2% in the Canadian population. This research project aims to develop innovative, neural-substrate based, and novel theoretical paradigms for understanding psychological trauma and its clinical outcomes, including problems in emotion regulation, self-awareness, social emotional and self-referential processing. Cuttingedge neuroimaging analyses will be utilized to compare the response of individuals with and without PTSD, with the ultimate goal of significantly improving treatment of PTSD. The implementation of advanced neuroimaging methodologies and the translation of evidence-based outcomes into clinical knowledge will benefit the partner organization as well as the health services providing treatment of PTSD. Dissemination of the results will also constitute an indirect benefit for all the parties involved.

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Faculty Supervisor:

Ruth Lanius

Student:

Partner:

Homewood Health Centre;Homewood Research Institute

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Professional, scientific and technical services

University:

Western University

Program:

Accelerate

The effect of an innovative parent training program to promote parental reflective function and child development in high-risk families

Parents suffering from toxic stress (depression, addictions, and/or family violence) are often unable to respond sensitively and appropriately to their infants, putting the health and development of their infants at risk. My research evaluates a new parenting program called ATTACH. In ATTACH, parents learn to reflect on how they parent and to better understand their own feelings and behavior and those of their children. We hope that ATTACH improves parents’ sensitivity and responsiveness to their infants and ultimately their children’s health and development. I will conduct this study with Calgary Urban Project Society (CUPS) that provides services to high-risk families. If effective, I expect this new ATTACH program will be commercializable and added to service agencies’ programs for high-risk families, such as CUPS. The Norlien Foundation is also a partner and study results directly address Norlien’s vision of supporting research and accelerating innovation to improve children’s health and development.

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Faculty Supervisor:

Nicole LeTourneau

Student:

Partner:

Calgary Urban Project Society;Norlien Foundation

Discipline:

Life Sciences

Sector:

Other services (except public administration)

University:

University of Calgary

Program:

Accelerate

Versatile applications of a safe and efficient peptide in gene/drug delivery – Year Two

Gene therapy is one of the most attractive new therapeutic strategies in the treatment of multiple diseases. However, to apply gene therapy in clinic, an efficient and safe delivery system must be developed to transport these therapeutic reagents to target organs. The existing gene carriers suffer from either high cytotoxicity or immunogenicity problems, which will cause severe side effects when used in human. The new peptide based delivery system we developed demonstrated better performance and lower toxicity than the commercialized product on market. Preliminary animal experiments also proved the great therapeutic potential of this novel peptide. Now we propose to further confirm the efficiency of this peptide on various cells from different tissues, as well as to extend the application to deliver other therapeutic molecules. The partner organization will benefit from the potential of commercializing a product with bright market prospect and promising therapeutic applications.

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Faculty Supervisor:

Pu Chen

Student:

Partner:

Positec Canada Ltd

Discipline:

Engineering

Sector:

Manufacturing; Professional, scientific and technical services

University:

University of Waterloo

Program:

Elevate

New strategies to improve the use of the predatory bug, Orius insidiosus, to control Western Flower Thrips, Frankliniella occidentalis, in greenhouse ornamental crops

The proposed research will investigate how to improve the performance and economic sustainability of Orius insidiosus as a biological control against Western Flower Thrips in greenhouse ornamental crops. New strategies to increase the efficiency of O. insidious will be investigated through the use of banker plants, supplemental food, and the use of lures. The project complements previous thrips research and will contribute to increased greenhouse production and profitability. Additionally, while the proposed research is targeted towards floriculture, there may be applicable uses for control in greenhouse vegetable and field crops as well. The research aligns closely with Eco Habitat Agri Services objectives of integration and implementation of biological control strategies in greenhouse oranmental crops. Results from this research will help develop company recommendations for greenhouse growers to ensure their biological control strategies are more reliable and economical.

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Faculty Supervisor:

Cynthia Scott-Dupree

Student:

Partner:

Discipline:

Life Sciences

Sector:

University:

University of Guelph

Program:

Accelerate

Versatile applications of a safe and efficient peptide in gene/drug delivery

Gene therapy is one of the most attractive new therapeutic strategies in the treatment of multiple diseases. However, to apply gene therapy in clinic, an efficient and safe delivery system must be developed to transport these therapeutic reagents to target organs. The existing gene carriers suffer from either high cytotoxicity or immunogenicity problems, which will cause severe side effects when used in human. The new peptide based delivery system we developed demonstrated better performance and lower toxicity than the commercialized product on market. Preliminary animal experiments also proved the great therapeutic potential of this novel peptide. Now we propose to further confirm the efficiency of this peptide on various cells from different tissues, as well as to extend the application to deliver other therapeutic molecules. The partner organization will benefit from the potential of commercializing a product with bright market prospect and promising therapeutic applications.

View Full Project Description
Faculty Supervisor:

Pu Chen

Student:

Partner:

Positec Canada Ltd

Discipline:

Engineering

Sector:

Manufacturing; Professional, scientific and technical services

University:

University of Waterloo

Program:

Elevate

Development and Delivery of Inhibitors for Viral Pathogenic Deubiquitinases – Year Two

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to evade the immune system by interfering with host ubiquitin-dependent processes. Unfortunately, the lack of molecules that can block the activity of viral deubiquitinases has severely hampered attempts to manipulate them for therapeutic benefits. The Sidhu group has invented a new technology to develop synthetic protein modulators for any ubiquitin-interacting proteins. The goal of this project is to generate highly specific and potent inhibitors for viral pathogenic deubiquitinases and a platform to deliver these molecules into human cells. This will lead to effective antiviral therapy, expanding the existing therapeutic portfolio of CCAB.

View Full Project Description
Faculty Supervisor:

Jason Moffat

Student:

Partner:

Centre for the Commercialization of Antibodies and Biologics

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Toronto

Program:

Elevate

Development and Delivery of Inhibitors for Viral Pathogenic Deubiquitinases

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to evade the immune system by interfering with host ubiquitin-dependent processes. Unfortunately, the lack of molecules that can block the activity of viral deubiquitinases has severely hampered attempts to manipulate them for therapeutic benefits. The Sidhu group has invented a new technology to develop synthetic protein modulators for any ubiquitin-interacting proteins. The goal of this project is to generate highly specific and potent inhibitors for viral pathogenic deubiquitinases and a platform to deliver these molecules into human cells. This will lead to effective antiviral therapy, expanding the existing therapeutic portfolio of CCAB.

View Full Project Description
Faculty Supervisor:

Jason Moffat

Student:

Partner:

Centre for the Commercialization of Antibodies and Biologics

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Toronto

Program:

Elevate

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