The project aims to translate developments in ultra-sensitive MRI sensors to a clinically-relevant setting. To create high-sensitivity sensors for better images, we aim to create a tight-fitting system which places the sensors—akin to antennas—closer to the brain. This will improve the quality of the signals that we can extract from the brain, and allow us […]

In adults, influenza vaccination is administered by intramuscular injection, a procedure that many people find painful and that some find frightening (ie: needle-phobia). Influenza vaccination is now encouraged or recommended for all Canadians. Every year, there is a large effort to vaccinate as many people as possible before the ‘flu season’. The urgency to vaccinate […]

NXTSens has developed an implantable continuous monitoring, stand-alone and potentially mass-producible microsensor for accurate monitoring of tissue pressure and temperature in damaged limb muscles to better diagnose ACS. The proposed research will involve several sub-projects that include: i) develop appropriate surgical models for the accurate and reproducible placement of the microsensors in rodent compartments; ii) […]

The laboratory’s research is composed of three key arms that make up the core of its work. These are: Anterior segment, Intraocular tumors (including melanoma, retinoblastoma and ocular lymphoma), and Imaging and its correlation with histopathology, (in particular of normal and diseased retina). Within these research arms are multiple projects that several members of the […]

We aim to develop tools to assess patient outcomes following treatment and removal of bone metastases. We will identify markers for enhanced patient outcomes, so as to predict which patients may benefit from more aggressive treatments to better their quality of life. We also aim to use 3D printed bone implants to help in the […]

Cataract surgery is one of the most common surgeries performed worldwide. The incidence of posterior capsule opacification (PCO) after cataract surgery, a serious complication that affects vision and requires additional treatment, is ~30%. In this study, we will investigate differences in PCO, presence of fibronectin, and ciliary ring distortion between lenses in eyes obtained from […]

G protein-coupled receptors (GPCRs), which are proteins normally found at the surface of cells, are involved in regulating virtually every physiological response. GPCRs activate numerous intracellular signaling mechanisms and are the targets of more than 30% of today’s prescribed drugs. These drugs have traditionally been thought to act as on/off switches to activate or inhibit […]

Many HIV-positive persons on HIV medication have trouble taking this medication as prescribed by their doctor (treatment adherence). This threatens the long-term ability of the drugs to preserve a patient’s health. For 1 in 5 in Canada, their medication does not work, in part because of adherence problems. Furthermore, doctors and their HIV-positive patients do […]

Patients with cervical spine degeneration are difficult to diagnose and treat. Some patients will not benefit from surgical intervention while others require immediate surgical management to avoid permanent neurological deficits. Distinguishing between these patient groups is very difficult, and not effectively done with current protocols. Medical imaging is part of the current diagnostic protocol for […]

Autism is a growing public health challenge in Canada and internationally. Despite major scientific advances in autism research and improvements in practice, families still experience serious delays and complications in diagnosis and access to care. Moreover, community capacity, e.g., treatment and support programs, remains very limited relative to the needs of those affected. In turn, […]

The objective of this project is to develop decellularized extracellular matrix-based biomaterials suitable for extrusion bioprinting that capture the properties of breast cancer that has metastasized to the lung, and then to use these biomaterials to culture cells into human tissues that can be used as accurate models for preclinical drug development.

The gut microbiota, a complex community of microorganisms residing within the digestive tract, plays a significant role in modulating host immune responses. This project aims to identify specific gut microbial species that influence the immune response and elucidate the underlying molecular mechanisms involved. To study these microbe-host interactions, mice cells will be exposed to different […]